The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia.

摘要: Objective: To provide evidence for the hypothesis that corticobasal degeneration syndrome (CBDs) overlaps significantly with primary progressive aphasia and frontotemporal dementia, CBDs is part of Pick complex. Background: Corticobasal has been mainly described as a movement disorder, but cognitive impairment also increasingly noted. Methods: Thirty-five cases clinically diagnosed were followed-up clinical, neuropsychological, neuroimaging investigations. Twenty-nine patients seen prospectively in disorder neurology clinics; five these came to autopsy. Six other autopsied fulfilled clinical criteria added retrospective review records. Results: All 15 presenting disorders developed behavioral, cognitive, or language deficits shortly after onset several years. Patients problems (n = 20), 13), dementia 7) subsequently. Eleven autopsy had CBD forms Conclusions: There overlap between CBD, aphasia. pathologic syndromes. The recognition this will facilitate diagnosis avoid consideration “heterogenous.”