Aldehyde-Catalyzed Transition Metal-Free Dehydrative β-Alkylation of Methyl Carbinols with Alcohols
作者： Qing Xu , Jianhui Chen , Quan Liu
关键词: Borrowing hydrogen 、 Aldol condensation 、 Chemistry 、 Alcohol 、 Alkylation 、 Catalysis 、 Alcohol oxidation 、 Aldehyde 、 Oppenauer oxidation 、 Organic chemistry
摘要: Different to the borrowing hydrogen strategy in which alcohols were activated by transition metal-catalyzed anaerobic dehydrogenation, direct addition of aldehydes was found be an effective but simpler way alcohol activation that can lead efficient and green aldehyde-catalyzed metal-free dehydrative C-alkylation methyl carbinols with alcohols. Mechanistic studies revealed reaction proceeds via situ formation ketones Oppenauer oxidation external aldehydes, aldol condensation, Meerwein–Ponndorf–Verley (MPV)-type reduction α,β-unsatutated substrate alcohols, affording useful long chain generating as by-products will recovered next condensation finish catalytic cycle.
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