What we truly know about occupation as a risk factor for ALS: a critical and systematic review.

摘要: Occupational and environmental exposures may contribute to the risk of developing sporadic amyotrophic lateral sclerosis (ALS). To summarize available evidence, a systematic review literature on occupation as potential determinant ALS was performed according MOOSE guidelines. From MEDLINE, EMBASE, CINAHL, Cochrane databases, selected studies were methodologically appraised Armon's classification system for factor studies. Each studied reclassified International Standard Classification Occupations (ISCO-88). The vote-counting method applied data. Of 3773 potentially relevant studies, 51 initially included. these, 12 provided estimates individual occupations--one case-control, two register-based nine cohort All fell into level evidence class IV, indicating methodological limitations. Due heterogeneity study methodology, data could not be pooled. revealed several candidate occupations: veterinarians other health workers, athletes, hairdressers, power-production plant, electrical military workers. However, well designed with standardized assessment are needed provide more definitive answer about exogenous factors ALS.