Effects of Rivaroxaban on Platelet Activation and Platelet–Coagulation Pathway Interaction In Vitro and In Vivo Studies
作者： Elisabeth Perzborn , Stefan Heitmeier , Volker Laux
关键词: Hemostasis 、 Platelet activation 、 Platelet aggregation inhibitor 、 Coagulation 、 Medicine 、 Ticagrelor 、 Pharmacology 、 Platelet 、 Tissue factor 、 Rivaroxaban
摘要: Introduction:Activation of coagulation and platelets is closely linked, arterial thrombosis involves activation as well platelet aggregation. In these studies, we investigated the possible synergistic effects rivaroxaban in combination with antiplatelet agents on thrombin generation aggregation vitro hemostasis rat models.Materials Methods:Thrombin was measured by Calibrated Automated Thrombogram method (0.5 pmol/L tissue factor) using human platelet-rich plasma (PRP) spiked (15, 30, or 60 ng/mL), ticagrelor (1.0 µg/mL), acetylsalicylic acid (ASA; 100 µg/mL). Tissue factor-induced PRP (15 30 (1 3 a these. An arteriovenous (AV) shunt model rats used to determine (0.01, 0.03, 0.1 mg/kg), clopidogrel ASA (3 combina...
sagepub.com
sci-hub.se 参考文章(36)
Leslie G. Cleland, Jennifer R. Gamble, Gillian E. Caughey, Michael J. James, Up-regulation of endothelial cyclooxygenase-2 and prostanoid synthesis by platelets. Role of thromboxane A2. Journal of Biological Chemistry. ,vol. 276, pp. 37839- 37845 ,(2001) , 10.1074/JBC.M010606200
E.M. BECKER, E. PERZBORN, A. KLIPP, C. LÜCKER, U. BÜTEHORN, R. KAST, J. J. BADIMON, V. LAUX, Effects of rivaroxaban, acetylsalicylic acid and clopidogrel as monotherapy and in combination in a porcine model of stent thrombosis. Journal of Thrombosis and Haemostasis. ,vol. 10, pp. 2470- 2480 ,(2012) , 10.1111/JTH.12033
Tom J. Parry, Zhihong Huang, Cailin Chen, Margery A. Connelly, Elisabeth Perzborn, Patricia Andrade-Gordon, Bruce P. Damiano, Arterial antithrombotic activity of rivaroxaban, an orally active factor Xa inhibitor, in a rat electrolytic carotid artery injury model of thrombosis. Blood Coagulation & Fibrinolysis. ,vol. 22, pp. 720- 726 ,(2011) , 10.1097/MBC.0B013E32834CB30E
Gerard M.T. Vogel, Dick G. Meuleman, Freek G.M. Bourgondiën, Paul M.J. Hobbelen, Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thrombosis Research. ,vol. 54, pp. 399- 410 ,(1989) , 10.1016/0049-3848(89)90210-7
Friedel Seuter, Inhibition of Platelet Aggregation by Acetylsalicylic Acid and other Inhibitors Pathophysiology of Haemostasis and Thrombosis. ,vol. 5, pp. 85- 95 ,(1976) , 10.1159/000214122
Kjell S. Sakariassen, Stephen R. Hanson, Yves Cadroy, Methods and Models to Evaluate Shear-Dependent and Surface Reactivity-Dependent Antithrombotic Efficacy Thrombosis Research. ,vol. 104, pp. 149- 174 ,(2001) , 10.1016/S0049-3848(01)00344-9
P. C. WONG, E. J. CRAIN, C. A. WATSON, B. XIN, Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits. Journal of Thrombosis and Haemostasis. ,vol. 7, pp. 1313- 1320 ,(2009) , 10.1111/J.1538-7836.2009.03503.X
Roger Vl, None, Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association Circulation. ,vol. 125, ,(2012) , 10.1161/CIR.0B013E31823AC046
Sukit M. Ringwala, Peter M. DiBattiste, David J. Schneider, Effects on platelet function of a direct acting antagonist of coagulation factor Xa Journal of Thrombosis and Thrombolysis. ,vol. 34, pp. 291- 296 ,(2012) , 10.1007/S11239-012-0727-5
Nana-Maria Wagner, Tobias Dressel, Katrin Schäfer, Stavros Konstantinides, Effect of the factor Xa inhibitor rivaroxaban on arterial thrombosis in wild-type and apolipoprotein E-deficient mice. Thrombosis Research. ,vol. 130, pp. 793- 798 ,(2012) , 10.1016/J.THROMRES.2012.01.002