New Direct Oral Anticoagulants (DOAC) and Their Use Today.

摘要: The ideal anticoagulant is oral, has a wide therapeutic range, predictable pharmacokinetics and pharmacodynamics, rapid onset of action, an available antidote, minimal side effects interactions with other drugs or food. With the development novel direct oral anticoagulants (DOAC), we now have alternative to traditional vitamin K antagonists (VKA) for prevention treatment thrombosis. DOACs limited monitoring requirements very pharmacokinetic profiles. They were shown be non-inferior superior VKA in prophylaxis thromboembolic events. Particularly terms safety they associated less major bleeding, including intracranial thus providing benefit stroke patients atrial fibrillation. Despite these advantages, there are remaining limitations DOACs: their dependence on renal hepatic function clearance lack approved reversal agent, whereas such antidotes successively being made available. do not need regular assess effect but, hand, interact interfere functional coagulation assays. From practical point view, properties administration, simple dosing without monitoring, short half-life allowing possibility uncomplicated switching bridging, proven overwhelm disadvantages, making them attractive option short- long-term anticoagulation.