Methods and apparatus for screening and detecting multiple genetic mutations
作者： Ray R. Radtkey , David Canter , Lance C. Held , Karen Menge , Robert B. Wallace
DOI:
关键词: Genetics 、 Single mutation 、 DNA 、 genomic DNA 、 Biology 、 Identification (biology)
摘要: An assay system and methods are described where patient samples containing genomic DNA analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In preferred embodiment, amplified is localized at test sites in an array on microchip followed by series hybridization reactions that screen single mutation from among number mutations, allow identification specific mutations. addition to reporters, may use blockers discriminators screening polymorphisms.
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