Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol.

摘要: It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On other hand, LPLs such lysophosphatidylserine (LPS), lysophosphatidylthreonine (LPT), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI) lysophosphatidylglycerol (LPG) been reported to show lipid mediator-like responses both vivo (LPS LPT) vitro (LPS, LPT, LPE LPG), while very little known about receptor, synthetic enzyme patho-physiological roles. In this review, we summarize actions these including LPS, LPG.