Molecular and cellular changes associated with neurofibrillary tangles and senile plaques
作者： J-P. Brion , M. E. Cheetham , M. Coleman , G. Dale , J-M. Gallo
DOI: 10.1007/978-3-7091-3396-5_13
关键词: Chemistry 、 Core protein 、 Senile plaques 、 Proteoglycan 、 Amyloid 、 Blot 、 Neurofibrillary tangle 、 Neurofilament 、 Pathology 、 Phosphorylation
摘要: Immunocytochemical studies have shown that changes in amyloid processing and proteoglycan core proteins occur senile plaques. Western blotting an extra tau species is present Alzheimer brain tangle-reactive neurofilament antibodies were found to be more selective towards phosphorylated neurofilaments than those do not recognise tangles. A fragment of MAP2 was
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C.C. Miller, J.P. Brion, R. Calvert, T.K. Chin, P.A. Eagles, M.J. Downes, J. Flament-Durand, M. Haugh, J. Kahn, A. Probst, Alzheimer's paired helical filaments share epitopes with neurofilament side arms. The EMBO Journal. ,vol. 5, pp. 269- 276 ,(1986) , 10.1002/J.1460-2075.1986.TB04209.X
M J Carden, W W Schlaepfer, V M Lee, The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state. Journal of Biological Chemistry. ,vol. 260, pp. 9805- 9817 ,(1985) , 10.1016/S0021-9258(17)39307-9
J. P. Brion, P. van den Bosch de Aguilar, J. Flament-Durand, Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies Advances in Applied Neurological Sciences: Senile Dementia of the Alzheimer type. Early diagnosis.. pp. 164- 174 ,(1985) , 10.1007/978-3-642-70644-8_13
Dashou Wang, Sally A. Lewis, Nicholas J. Cowan, Complete sequence of a cDNA encoding mouse MAP2. Nucleic Acids Research. ,vol. 16, pp. 11369- 11370 ,(1988) , 10.1093/NAR/16.23.11369
Kieran C. Breen, Philip A. Robinson, Didier Wion, Brian H. Anderton, Partial sequence of the rat heavy neurofilament polypeptide (NF-H) Identification of putative phosphorylation sites FEBS Letters. ,vol. 241, pp. 213- 218 ,(1988) , 10.1016/0014-5793(88)81064-0
A. Probst, H. Brunnschweiler, C. Lautenschlager, J. Ulrich, A special type of senile plaque, possibly an initial stage Acta Neuropathologica. ,vol. 74, pp. 133- 141 ,(1987) , 10.1007/BF00692843
B. Wolozin, A. Scicutella, P. Davies, Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 6202- 6206 ,(1988) , 10.1073/PNAS.85.16.6202
Gregory M. Cole, Paola S. Timiras, Ubiquitin-protein conjugates in Alzheimer's lesions. Neuroscience Letters. ,vol. 79, pp. 207- 212 ,(1987) , 10.1016/0304-3940(87)90698-7
B. Wolozin, A Pruchnicki, D. Dickson, P Davies, A neuronal antigen in the brains of Alzheimer patients Science. ,vol. 232, pp. 648- 650 ,(1986) , 10.1126/SCIENCE.3083509
Laszlo Otvos, Miklos Hollosi, Andras Perczel, Bernhard Dietzschold, Gerald D Fasman, None, Phosphorylation loops in synthetic peptides of the human neurofilament protein middle-sized subunit. Journal of Protein Chemistry. ,vol. 7, pp. 365- 376 ,(1988) , 10.1007/BF01024886