Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.
作者： B. Wolozin , A. Scicutella , P. Davies
关键词:
摘要: ALZ-50 is a monoclonal antibody that recognizes protein of apparent molecular mass 68 kilodaltons (A68). The present in the brains patients with Alzheimer disease but not detectable normal adult brain tissue. We now report ALZ-50-reactive neurons are found fetal and neonatal human tissue from individuals Down syndrome. Reactive decrease sharply number after age 2 reappear older syndrome disease.
core.ac.uk
harvard.edu
osti.gov
sci-hub.se 参考文章(16)
L L Heston, Down's syndrome and Alzheimer's dementia: defining an association Psychiatric developments. ,vol. 2, pp. 287- 294 ,(1984)
Robert Katzman, Biological aspects of Alzheimer's disease Cold Spring Harbor Laboratory. ,(1983)
Vogel Fs, Burger Pc, The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. American Journal of Pathology. ,vol. 73, pp. 457- 476 ,(1973)
MB Luskin, CJ Shatz, Studies of the earliest generated cells of the cat's visual cortex: cogeneration of subplate and marginal zones The Journal of Neuroscience. ,vol. 5, pp. 1062- 1075 ,(1985) , 10.1523/JNEUROSCI.05-04-01062.1985
B. Wolozin, A Pruchnicki, D. Dickson, P Davies, A neuronal antigen in the brains of Alzheimer patients Science. ,vol. 232, pp. 648- 650 ,(1986) , 10.1126/SCIENCE.3083509
Joel S. Pachter, Ronald K.H. Liem, The differential appearance of neurofilament triplet polypeptides in the developing rat optic nerve Developmental Biology. ,vol. 103, pp. 200- 210 ,(1984) , 10.1016/0012-1606(84)90021-6
B. T. Hyman, G. W. Van Hoesen, B. L. Wolozin, P. Davies, L. J. Kromer, A. R. Damasio, Alz‐50 Antibody recognizes alzheimer‐related neuronal changes Annals of Neurology. ,vol. 23, pp. 371- 379 ,(1988) , 10.1002/ANA.410230410
LESTER I. BINDER, ANTHONY FRANKFURTER, LIONEL I. REBHUN, Differential localization of MAP-2 and tau in mammalian neurons in situ. Annals of the New York Academy of Sciences. ,vol. 466, pp. 145- 166 ,(1986) , 10.1111/J.1749-6632.1986.TB38392.X
Ivica Kostovic, Pasko Rakic, Cytology and time of origin of interstitial neurons in the white matter in infant and adult human and monkey telencephalon. Journal of Neurocytology. ,vol. 9, pp. 219- 242 ,(1980) , 10.1007/BF01205159
J J_M Chun, MJ Nakamura, CJ Shatz, None, Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons Nature. ,vol. 325, pp. 617- 620 ,(1987) , 10.1038/325617A0