Thyroid function and plasma immunoglobulins in subjects with Down’s syndrome (DS) during ontogenesis and zinc therapy
作者： M. S̆ustrová , Vladimir S̆trbák
DOI: 10.1007/BF03347724
关键词:
摘要: Thyroid function parameters and immunoglobulin concentrations in sera of outpatients with Down’s syndrome (DS, n=110) different ages (DS1= 1–9 years; DS2= 6–15; DS3= 15–35) were compared those age-matched controls (n=110). Although mean serum TSH was higher all DS groups, thyroid hormone significantly lower only DS3. In DS1, a notable frequency rate high T4 T3 found. Serum thyroxine binding globulin (TBG) groups. Free indexes, calculated as the ratio total hormone: TBG concentrations, IgA DS1 DS2. zinc levels Repeated examination after one year revealed patients treated during this interval to values observed before treatment. Our results suggest occurrence complex immune endocrine disorders dysregulation patients, deficiency playing considerable role.
springer.com
sci-hub.se 参考文章(23)
Bucci I, Palka G, Napolitano G, Stuppia L, Lio S, De Remigis P, Monaco F, Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome Annales De Genetique. ,vol. 33, pp. 9- 15 ,(1990)
R Maccario, A Lanzavecchia, A G Ugazio, G R Burgio, A Vitiello, A Plebani, Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children. Clinical and Experimental Immunology. ,vol. 33, pp. 298- 301 ,(1978)
Leslie Wada, Janet C. King, Effect of Low Zinc Intakes on Basal Metabolic Rate, Thyroid Hormones and Protein Utilization in Adult Men The Journal of Nutrition. ,vol. 116, pp. 1045- 1053 ,(1986) , 10.1093/JN/116.6.1045
B. Wolozin, A. Scicutella, P. Davies, Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 6202- 6206 ,(1988) , 10.1073/PNAS.85.16.6202
Federico Licastro, Eugenio Mocchegiani, Maria Zannotti, Massimo Masi, Giuseppe Arena, Nicola Fabris, Zinc affects the metabolism of thyroid hormones in children with Down's syndrome: normalization of thyroid stimulating hormone and of reversal triiodothyronine plasmic levels by dietary zinc supplementation. International Journal of Neuroscience. ,vol. 65, pp. 259- 268 ,(1992) , 10.3109/00207459209003299
Siegfried M. Pueschel, Thyroid Dysfunction in Down Syndrome Archives of Pediatrics & Adolescent Medicine. ,vol. 139, pp. 636- 639 ,(1985) , 10.1001/ARCHPEDI.1985.02140080106045
Roberto T. Zori, Desmond A. Schatz, Harry Ostrer, Charles A. Williams, Rebecca Spillar, William J. Riley, Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome. American Journal of Medical Genetics. ,vol. 7, pp. 238- 241 ,(2005) , 10.1002/AJMG.1320370748
E d. H Lobo, M Khan, J Tew, Community study of hypothyroidism in Down's syndrome. BMJ. ,vol. 280, pp. 1253- 1253 ,(1980) , 10.1136/BMJ.280.6226.1253
M M Loudon, R E Day, E M Duke, Thyroid dysfunction in Down's syndrome. Archives of Disease in Childhood. ,vol. 60, pp. 1149- 1151 ,(1985) , 10.1136/ADC.60.12.1149
Teresa Sharav, Growth Studies in Infants and Children With Down's Syndrome and Elevated Levels of Thyrotropin Archives of Pediatrics & Adolescent Medicine. ,vol. 142, pp. 1302- 1306 ,(1988) , 10.1001/ARCHPEDI.1988.02150120056040