Synthesis, characterization, DNA binding, and cytotoxic studies of some mixed-ligand palladium(II) and platinum(II) complexes of α-diimine and amino acids
作者： Renu Mital , T.S. Srivastava , H.K. Parekh , M.P. Chitnis
DOI: 10.1016/0162-0134(91)80003-Z
关键词: Amino acid 、 Infrared spectroscopy 、 Palladium 、 Chemistry 、 Proton NMR 、 Stereochemistry 、 Hydrogen bond 、 Glycine 、 Diimine 、 2,2'-Bipyridine
摘要: Abstract The syntheses of nine palladium(II) complexes type [Pd(phen)(AA)] + (where AA is an anion glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, L-tryptophan, L-valine, L-proline, or L-serine) have been achieved. These characterized by ultraviolet-visible, infrared, and 1 H NMR spectroscopy. binding studies several [M(NN)(AA)] M Pd(II) as Pt(II), NN 2,2′-bipyridine 1,10-phenanthrodine, amino acid) with calf thymus DNA carried out using UV difference absorption fluorescence mode the above to suggests involvement hydrogen bonding between them. Several [M(phen)(AA)] Pt(II) also screened for cytotoxicity in P388 lymphocytic cells. Of them, only two complexes, [Pd(Phen)(Gly)] [Pd(phen)(Val)] , show comparable cytotoxicity, cisplatin does.
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