Synthesis, characterization, and cytotoxic studies of α-diimine/1,2-diamine platinum(II) and palladium(II) complexes of selenite and tellurite and binding of some of these complexes to DNA
作者： H Mansuri-Torshizi
DOI: 10.1016/0162-0134(91)84029-9
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摘要: Abstract Eleven new complexes of formula [M(NN)(XO 3 )] (where M is Pd(II) or Pt(II); NN 2,2′-bipyridine, 1,10-phenanthroline, 2,2′-dipyridylamine, ethylenediamine (±) trans -1,2-diaminocyclohexane, and XO 2− SeO 2 − TeO ) have been synthesized. These water soluble characterized by chemical analysis conductivity measurements as well ultraviolet-visible infrared spectroscopy. In these the selenite tellurite ligand coordinates to platinum(II) palladium(II) bidentate with two oxygen atoms. inhibit growth P 388 lymphocytic leukemia cells, their targets are DNA. The invariably show I.D. 50 values less than cisplatin. However, usually higher cisplatin, except that [Pd(dach)(TeO which has comparable values, compared [Pt(bipy)(SeO [Pd(bipy)(SeO interacted calf thymus DNA bind through a coordinate covalent bond.
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