作者: Matthew P. Hanley , Daniel W. Rosenberg
DOI: 10.1007/S40495-015-0028-8
关键词: DNA methylation 、 Folic acid 、 Molecular medicine 、 Homeostasis 、 Inflammation 、 Nucleotide synthesis 、 Carcinogenesis 、 Biology 、 Cancer research 、 Colorectal cancer 、 Biochemistry
摘要: For many years folic acid has been evaluated for its utility as a chemopreventive agent due to position at the center of one-carbon metabolic network. This network is responsible generating precursors nucleotide synthesis well moieties used in DNA methylation reactions, two mechanisms which are frequently disrupted during carcinogenesis. While use chemoprevention colorectal cancer still controversial, there evidence that intake significant influence on these fundamental cellular mechanisms. Folic dual role with regards and (CRC) prevention; healthy colon, adequate folate status important metabolism homeostasis maintenance integrity, however colon harboring premalignant lesions lowered may help eliminate transformed cells. In addition, generation groups modulation be useful combating aberrant Interestingly, it revealed decreased can dampen inflammatory response, recently popular strategy chemoprevention. this review we discuss molecular influenced by how they might relevant greater detail.