One-Carbon Metabolism and Colorectal Cancer: Potential Mechanisms of Chemoprevention

作者: Matthew P. Hanley , Daniel W. Rosenberg

DOI: 10.1007/S40495-015-0028-8

关键词: DNA methylationFolic acidMolecular medicineHomeostasisInflammationNucleotide synthesisCarcinogenesisBiologyCancer researchColorectal cancerBiochemistry

摘要: For many years folic acid has been evaluated for its utility as a chemopreventive agent due to position at the center of one-carbon metabolic network. This network is responsible generating precursors nucleotide synthesis well moieties used in DNA methylation reactions, two mechanisms which are frequently disrupted during carcinogenesis. While use chemoprevention colorectal cancer still controversial, there evidence that intake significant influence on these fundamental cellular mechanisms. Folic dual role with regards and (CRC) prevention; healthy colon, adequate folate status important metabolism homeostasis maintenance integrity, however colon harboring premalignant lesions lowered may help eliminate transformed cells. In addition, generation groups modulation be useful combating aberrant Interestingly, it revealed decreased can dampen inflammatory response, recently popular strategy chemoprevention. this review we discuss molecular influenced by how they might relevant greater detail.

参考文章(74)
Shishir K. Das, Thomas A. Kunkel, Lawrence A. Loeb, Effects of Altered Nucleotide Concentrations on the Fidelity of DNA Replication Basic life sciences. ,vol. 31, pp. 117- 126 ,(1985) , 10.1007/978-1-4613-2449-2_7
Randall G. Richards, Oliver E. Brown, W. David Sedwick, Misincorporation of deoxyuridine in human cells: consequences of antifolate exposure. Basic life sciences. ,vol. 31, pp. 149- 162 ,(1985) , 10.1007/978-1-4613-2449-2_9
J E Baggott, S L Morgan, T Ha, W H Vaughn, R J Hine, Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs Biochemical Journal. ,vol. 282, pp. 197- 202 ,(1992) , 10.1042/BJ2820197
Ashwin Woodhoo, Marta Varela-Rey, Shelly C Lu, Maria-Luz Martinez-Chantar, José M Mato, Alcohol, DNA methylation, and cancer. Alcohol Res , 35 (1) pp. 25-35. (2013). ,vol. 35, pp. 25- 35 ,(2013)
Barry Shane, Folylpolyglutamate Synthesis and Role in the Regulation of One-Carbon Metabolism Vitamins and Hormones Series. ,vol. 45, pp. 263- 335 ,(1989) , 10.1016/S0083-6729(08)60397-0
Andrew P. Feinberg, Melanie Ehrlich, Kenneth C. Kuo, Charles W. Gehrke, Reduced Genomic 5-Methylcytosine Content in Human Colonic Neoplasia Cancer Research. ,vol. 48, pp. 1159- 1161 ,(1988)
Christina Dahl, Per Guldberg, DNA methylation analysis techniques. Biogerontology. ,vol. 4, pp. 233- 250 ,(2003) , 10.1023/A:1025103319328
S J Duthie, G Grant, S Narayanan, Increased uracil misincorporation in lymphocytes from folate-deficient rats. British Journal of Cancer. ,vol. 83, pp. 1532- 1537 ,(2000) , 10.1054/BJOC.2000.1481
Gabriela Lewin, Alaa Rostom, Catherine Dube, Use of Aspirin and NSAIDs to Prevent Colorectal Cancer Series:U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. ,(2007)
Young-In Kim, Joel B. Mason, Jacquelin Song, Alan Medline, Steven Gallinger, Effects of Dietary Folate on Intestinal Tumorigenesis in the ApcMin Mouse Cancer Research. ,vol. 60, pp. 5434- 5440 ,(2000)