Роль адренорецепторов в реализации стимуляторного действия серотонина на моторику желудка
作者： V. M. Smirnov , D. S. Sveshnikov , A. V. Kuchuk , T. E. Kuznetsova , O. S. Raevskaya
DOI: 10.31146/1682-8658-ECG-170-10-52-56
关键词: Pharmacology 、 Adrenergic receptor 、 Motor activity 、 Stomach 、 Serotonin 、 Blockade 、 Hydrostatic pressure 、 Medicine
摘要: Purpose of the study — role adrenoreceptors in development stimulatory action serotonin on gastric motor activity. Materials and methods. The experiments were performed rats (27) Wistar line surgical stage anesthesia. Electromyogram hydrostatic pressure stomach cavity recorded using a BioAmp ML132 amplifier (Adinstruments, Australia), an Maclab 8e analog-to-digital converter Macintosh Performa 6400/180 computer, Chart 4.2.3. program. Serotonin injected into body to intact animals against background separate joint blockade α- β-adrenoreceptors. results study. In established that preliminary simultaneous β- leads increase effect with introduction by 58%, α-adrenoreceptors only 62%, β-adrenoreceptor 89%. animals, eff ect is + 26%. Simultaneous β-adrenoreceptors (without administration) did not aff activity animals. Blockade will lead contractions 34%. Conclusion. Intact inhibit
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