Modifications of plasma 5-HT concentrations during the allergic bronchoconstriction in guinea pigs
作者： José Luis Arreola-Ramírez , Dr. Mario H. Vargas , Gabriel Manjarrez-Gutiérrez , Jesús Alquicira , Julio Gutiérrez
DOI: 10.3109/01902148.2013.805855
关键词:
摘要: ABSTRACTSeveral contractile mediators involved in the antigen-induced airway obstruction have been identified, but role of 5-HT (5-hydroxytryptamine or serotonin) has scantily investigated. In this work, potential allergic bronchoconstriction was evaluated through a pharmacological approach and plasma measurement blood samples from right left ventricles anesthetized guinea-pigs. Intravenous caused dose-dependent increase lung resistance anesthetized, nonsensitized guinea pigs. Likewise, sensitized animals antigenic challenge with ovalbumin also transient (356 ± 60% basal value), which largely inhibited by blockade serotonergic receptors methiothepin plus tropisetron (134 10%, P = .007). Sensitized tended to concentrations higher than controls, shortly after peak levels ventricle...
informahealthcare.com参考文章(21)
Kerry J. Rhoden, Alicia M. Dodson, Betty Ky, Stimulation of the Na(+)-K(+) pump in cultured guinea pig airway smooth muscle cells by serotonin. Journal of Pharmacology and Experimental Therapeutics. ,vol. 293, pp. 107- 112 ,(2000)
Fuad Lechin, Bertha van der Dijs, Beatriz Orozco, Marcel Lechin, Alex E Lechin, Increased levels of free serotonin in plasma of symptomatic asthmatic patients. Annals of Allergy Asthma & Immunology. ,vol. 77, pp. 245- 253 ,(1996) , 10.1016/S1081-1206(10)63263-2
Yun Wang, Andrew G. Ramage, David Jordan, Mediation by 5-HT3 receptors of an excitatory effect of 5-HT on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. British Journal of Pharmacology. ,vol. 118, pp. 1697- 1704 ,(1996) , 10.1111/J.1476-5381.1996.TB15594.X
P. Segura, M. H. Vargas, G. Córdoba-Rodríguez, J. Chávez, J. L. Arreola, P. Campos-Bedolla, V. Ruiz, L. M. García-Hernández, C. Méndez, L. M. Montaño, Role of 5-HT2A, 5-HT4 and 5-HT7 receptors in the antigen-induced airway hyperresponsiveness in guinea-pigs Clinical & Experimental Allergy. ,vol. 40, pp. 327- 338 ,(2010) , 10.1111/J.1365-2222.2009.03412.X
Fuad Lechin, Bertha van der Dijs, Beatriz Orozco, Hector Jara, Isais Rada, Marcel E. Lechin, Alex E. Lechin, Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: A double‐blind, crossover placebo‐controlled study Clinical Pharmacology & Therapeutics. ,vol. 64, pp. 223- 232 ,(1998) , 10.1016/S0009-9236(98)90156-4
Carlos M Villalón, David Centurión, Guadalupe Bravo, Peter De Vries, Pramod R Saxena, Mario I Ortiz, None, Further pharmacological analysis of the orphan 5-HT receptors mediating feline vasodepressor responses: close resemblance to the 5-HT7, receptor. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 361, pp. 665- 671 ,(2000) , 10.1007/S002100000256
Claire Roberts, Gary W Price, Brian J Jones, The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig European Journal of Pharmacology. ,vol. 326, pp. 23- 30 ,(1997) , 10.1016/S0014-2999(97)00156-8
Takeshi Nabe, Naoki Shinoda, Masahiro Yamada, Tomohiko Sekioka, Yuji Saeki, Hideki Yamamura, Shigekatsu Kohno, Repeated Antigen Inhalation-Induced Reproducible Early and Late Asthma in Guinea Pigs. The Japanese Journal of Pharmacology. ,vol. 75, pp. 65- 75 ,(1997) , 10.1254/JJP.75.65
Michael A. Peat, James W. Gibb, High-performance liquid chromatographic determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection Analytical Biochemistry. ,vol. 128, pp. 275- 280 ,(1983) , 10.1016/0003-2697(83)90375-5
MJ Cushley, LH Wee, ST Holgate, The effect of inhaled 5‐hydroxytryptamine (5‐HT, serotonin) on airway calibre in man. British Journal of Clinical Pharmacology. ,vol. 22, pp. 487- 490 ,(1986) , 10.1111/J.1365-2125.1986.TB02923.X