Syzygium guineense (Myrtaceae.Willd.) Leaf Extracts Inhibit Drug Efflux and Enhance Protein Leakage in Mycobacterium aurum and Mycobacterium smegmatis
作者： Deeds Mushayavanhu , Theresa Chimponda , Stanley Mukanganyama
DOI: 10.1080/22311866.2016.1268067
关键词: Microbiology 、 Mycobacterium tuberculosis 、 Efflux 、 Mycobacterium smegmatis 、 Pharmacology 、 Mycobacterium aurum 、 Mechanism of action 、 Biology 、 Antimycobacterial 、 Broth microdilution 、 Syzygium guineense
摘要: AbstractIsoniazid and rifampicin form the backbone for current treatment of tuberculosis. The emergence resistance to these drugs other second line has made tuberculosis difficult. There is need, thus, discover new that are free or can modify mechanism in Mycobacterium This study investigated antimycobacterial effects leaf extracts from Syzygium guineense on aurum smegmatis. broth microdilution method was used screening growth inhibitory activity. action showed potent activity tested by determining its protein leakage inhibition transport across cell membrane. methanol extract found be most inhibited mycobacterial growth. also cause proteins mycobacteria, inhibit drug efflux membrane anta...
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