Antimycobacterial activities of selected medicinal plants from Zimbabwe against Mycobacterium aurum and Corynebacterium glutamicum.
作者： S Mukanganyama , T Chimponda
DOI:
关键词: Biology 、 Mycobacterium aurum 、 Efflux 、 Antibiotics 、 Antimycobacterial 、 Parinari curatellifolia 、 Microbiology 、 Agar diffusion test 、 Corynebacterium glutamicum 、 Mycobacterium tuberculosis
摘要: The spread of multi-drug resistant tuberculosis necessitates the discovery new classes antibacterials and compounds that inhibit macromolecules involved in these mechanisms. Thirty ethanol extracts from nineteen selected plants Zimbabwe were screened against Mycobacterium aurum Corynebacterium glutamicum using agar disk diffusion method. These two organisms used as models for tuberculosis. amount ciprofloxacin accumulated effluxed by test organism was to determine whether plant could also act drug efflux pump inhibitors. Vernonia adoensis Mangifera indica at 500 mg/disk had highest growth inhibitory activity M. C. respectively. extract Parinari curatellifolia an MIC 8 μg/ MBC 63 μg/disk; 125 μg/disk >500 All bacteriostatic showed antagonistic effects when combined with rifampicin. P. made accumulate ciprofloxacin. accumulation caused greater than inhibitor reserpine. This may serve a source lead search antimycobacterials mechanisms action.
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