Acid–base effects, light emission, DNA-binding and photocleavage studies of oligo-homonuclear ruthenium(II) complexes and their computational study
作者： B Senthamarai Kannan , D Suresh Kumar , R Host Antony David , A Stalin , S Ignacimuthu
DOI: 10.1016/J.ICA.2015.03.042
关键词: Light emission 、 Chemistry 、 Crystallography 、 Phenanthroline 、 Ruthenium 、 Intercalation (chemistry) 、 Ionic bonding 、 Imidazole 、 Hydrogen bond 、 Photochemistry 、 Affinities
摘要: Abstract The ground- and excited-state acid ionization constants the DNA binding properties of mono-, di- trinuclear ruthenium(II) polypyridine complexes have been studied by electronic absorption fluorescence emission spectroscopy. abilities increase with increasing π-electron multiplicity phenanthroline groups H-bonding imidazole moieties from mononuclear (R1) to dinuclear (R2), followed (R3) complexes. In addition, surface area relatively leads a corresponding enhancement in affinity. DNA-binding constants, Kb, were determined systematically spectrophotometric titration. addition various ionic interactions, van der Waals interaction, hydrogen bonding, Kb hypochromism Ru(II) inferred existence intercalation mode binding. trend affinities as well spectral this series can be reasonably explained applying DFT at B3LYP/LanL2DZ/6-31G level. results suggest that multiplication complex unit has important effects on structures, an improvement affinity ruthenium biological receptors namely, G-quadraplexes human telomeres investigated. characteristics compared each other using molecular docking. Further, these tend promote cleavage plasmid under photolytic conditions.
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