Trans- and cis- 2-phenylindole platinum(II) complexes as cytotoxic agents against human breast adenocarcinoma cell lines
作者： Ramon Messeguer , Laura Baldomá , Josefa Badía , Maria Tomé , Concepción López
DOI: 10.1016/J.MOLSTRUC.2013.04.071
关键词: Derivative (chemistry) 、 Stereochemistry 、 Mechanism of action 、 Oxime 、 Crystal structure 、 Platinum 、 Cisplatin 、 Indole test 、 Chemistry 、 Cis–trans isomerism
摘要: Abstract The synthesis and characterization of the new 2-phenylindole derivative: C 8 H 3 N-2-C 6 5 -3NOMe-5OMe ( 3c ) trans- cis- isomers [Pt( )Cl 2 (DMSO)] complexes 4c 5c , respectively) are described. crystal structures ·CH Cl confirm: (a) existence a Pt-N indole bond, (b) relative arrangement − ligands [ (in or )] (c) anti- E configuration oxime. cytotoxic assessment N-2-(C 4 -4′R 1 )-3NOMe-5R [with R = R = H 3a ); = Cl, 3b = H, = OMe geometrical [Pt(L)Cl with L = – 4a 5a ), respectively] against human breast adenocarcinoma cell lines (MDA-MB231 MCF-7) is also reported reveals that all platinum(II) (except more than cisplatin in front MCF7 line. Electrophoretic DNA migration studies synthesized compounds absence presence topoisomerase-I have been performed, order to get further insights into their mechanism action.
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sci-hub.se 参考文章(89)
Edwin Constable, Comprehensive coordination chemistry II : from biology to nanotechnology Elsevier. ,(2004)
Ahmed Abdullah, Fazlul Huq, Ashraf Chowdhury, Hasan Tayyem, Philip Beale, Keith Fisher, Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine. BMC Chemical Biology. ,vol. 6, pp. 3- 3 ,(2006) , 10.1186/1472-6769-6-3
Wilfred Louis Florio Armarego, Douglas Dalzell Perrin, D. R Perrin, Purification of laboratory chemicals ,(1966)
Gautam R. Desiraju, Thomas Steiner, The Weak Hydrogen Bond: In Structural Chemistry and Biology ,(1999)
Aleksandr Isaakovich Kitaĭgorodskiĭ, Molecular crystals and molecules Academic Press. ,(1973)
Elzbieta Budzisz, Magdalena Malecka, Barbara Nawrot, Synthesis and structure of highly substituted pyrazole ligands and their complexes with platinum(II) and palladium(II) metal ions Tetrahedron. ,vol. 60, pp. 1749- 1759 ,(2004) , 10.1016/J.TET.2003.12.044
DN Reinhoudt, M Crego-Calama, Synthesis Beyond the Molecule Science. ,vol. 295, pp. 2403- 2407 ,(2002) , 10.1126/SCIENCE.1069197
José Ruiz, Julia Lorenzo, Consuelo Vicente, Gregorio López, José María López-de-Luzuriaga, Miguel Monge, Francesc X. Avilés, Delia Bautista, Virtudes Moreno, Antonio Laguna, New palladium(II) and platinum(II) complexes with 9-aminoacridine: structures, luminiscence, theoretical calculations, and antitumor activity. Inorganic Chemistry. ,vol. 47, pp. 6990- 7001 ,(2008) , 10.1021/IC800589M
Robert Gastpar, Michael Goldbrunner, Doris Marko, Erwin von Angerer, Methoxy-Substituted 3-Formyl-2-phenylindoles Inhibit Tubulin Polymerization Journal of Medicinal Chemistry. ,vol. 41, pp. 4965- 4972 ,(1998) , 10.1021/JM980228L
Mauro Coluccia, Giovanni Natile, Trans-Platinum Complexes in Cancer Therapy Anti-cancer Agents in Medicinal Chemistry. ,vol. 7, pp. 111- 123 ,(2007) , 10.2174/187152007779314080