Single nucleotide polymorphisms and haplotypes in Native American populations.

摘要: Autosomal DNA polymorphisms can pro- vide new information and understanding of both the ori- gins relationships among modern Native American populations. At same time that autosomal markers be highly informative, they are also susceptible to ascer- tainment biases in selection use. Identifying used for ancestry inference populations considered sep- arate from identifying further quest his- tory. In current study, we using data on nine compare results based a large haplotype-based dataset with relatively small inde- pendent sets single nucleotide polymorphisms. We interested what types limited datasets an individual laboratory might able collect best addressing two different questions interest. First, how well differentiate and/or infer by assigning her population(s) origin? Second, historical/ evolutionary popula- tions their Eurasian origins? conclude only comprehensive involving multiple will answer questions; one or other these questions. Using our largest dataset, see general increasing distance Old World North South New except unexplained close relationship between Maya Quechua samples. Am J Phys Anthropol 146:495-502, 2011. V