Hydroquinone-O,O′-diacetic acid (‘Q-linker’) as a replacement for succinyl and oxalyl linker arms in solid phase oligonucleotide synthesis

作者: R. T. Pon , S. Yu

DOI: 10.1093/NAR/25.18.3629

关键词: PiperidineCombinatorial chemistryHydroquinoneOligoribonucleotidesPotassium carbonateBiochemistryOligonucleotide synthesisLinkerPyridineTriethylamineBiology

摘要: When hydroquinone-O,O′-diacetic acid is used as a linker arm in solid phase oligonucleotide synthesis, the time for NH 4 OH cleavage of oligodeoxy- or oligoribonucleotides is …

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