Should ICSI be the treatment of choice for all cases of in-vitro conception?No, not in light of the scientific data

作者: S. Oehninger

DOI: 10.1093/HUMREP/17.9.2237

关键词: BioinformaticsGerminal cellPregnancySemenSemen analysisIntracytoplasmic sperm injectionBiologyGynecologySperm

摘要: There is an ongoing debate among reproductive endocrinologists and embryologists about the indications for ICSI in management of infertile couple. Analysis published results indicates that there are no data to suggest should be performed all cases in-vitro conception. If basic semen analysis sperm function tests demonstrate impairment fertilizing capacity, couples directed ICSI. In previous fertilization failure, usually improved outcome. This suggests presence 'occult' male or female gamete defects can bypassed by We stress efforts geared toward identification aetiology pathophysiology oocyte lesions/dysfunctions responsible their potential contributions defective embryogenesis. A better definition needed, together with development directed, simpler, less expensive safer alternatives.

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