Some delayed effects of atom-bomb radiations in mice.

摘要: Summary 1.Male and female (C57L × A/He)F 1 mice surviving instantaneous exposure to ionizing radiation from an experimental nuclear detonation were observed until natural death for delayed effects of irradiation. 2.Among the was shortening lifespan, which varied with dose. 3.The life not attributable increased mortality any specific cause but correlated premature onset all diseases associated senescence. 4.Although on incidence severity old age markedly one disease another, advanced in essentially same extent by dose radiation, exception thymic lymphoma. 5.The lymphoma hastened considerably more than that other disease, particularly heavily irradiated mice, also had elevated this neoplasm. 6.There no consistent over-all relation between frequency neoplasia The certain neoplasms (thymic lymphoma, adenocarcinoma mammary gland, pituitary adenoma, adrenal Harderian gland hepatoma, ovarian tumor, granulocytic leukemia) irradiation, whereas others (pulmonary sarcoma, nonthymic lymphoma) decreased. In instance there a linear tumor Most less common after large doses intermediate doses, suggesting inhibited excessive injury. 7.Depigmentation hair, detected as early 3 months progressed at rate dose, it lightly or controls. 8.Cataract optic lens, noted within 90 days cataracts differed location opacities occurring spontaneously senile 9.Atrophy iris, developed senescent controls, occurred prematurely 10.Radiation nephritis, nephrosclerosis, receiving 400 rad rare below level. few polyarteritis kidney elsewhere. 11.Miscellaneous infectious inflammatory lesions, relatively 12.Subcapsular cysts hydrometra, aging reduced females, possibly through sterilization ovary. 13.Loss incisor teeth high proportion males nearly 10 times females. Its significantly affected 14.For most observed, neutrons effective gamma rays. Because, however, uncertainties dosimetry small numbers neutron-exposed animals, precise estimation relative effectiveness cannot be made results experiment.