Reverse Engineering Gene Network Identifies New Dysferlin-interacting Proteins
作者： Mafalda Cacciottolo , Vincenzo Belcastro , Steve Laval , Kate Bushby , Diego di Bernardo
关键词: Dysferlin 、 Cell biology 、 Limb-girdle muscular dystrophy 、 Gene regulatory network 、 Moesin 、 Transmembrane protein 、 PTRF 、 Membrane protein 、 Genetics 、 Biology 、 Regulation of gene expression 、 Biochemistry 、 Molecular biology
摘要: Dysferlin (DYSF) is a type II transmembrane protein implicated in surface membrane repair of muscle. Mutations dysferlin lead to Limb Girdle Muscular Dystrophy 2B (LGMD2B), Miyoshi Myopathy (MM), and Distal with Anterior Tibialis onset (DMAT). The DYSF complex not well understood, only few protein-binding partners have been identified thus far. To increase the set interacting for we recovered list predicted through systems biology approach. predictions are part "reverse-engineered" genome-wide human gene regulatory network obtained from experimental data by computational analysis. reverse-engineering algorithm behind analysis relates genes each other based on changes their expression patterns. AHNAK were used query system extract lists potential proteins. Among 32 two share, validated physical interaction between moesin (MSN) polymerase I transcript release factor (PTRF) mouse heart lysate, identifying novel Dysferlin-interacting Our strategy could be useful clarify function intracellular vesicles its implication muscle resealing.
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