Induction of cell death in human immunodeficiency virus-infected macrophages and resting memory CD4 T cells by TRAIL/Apo2l.
作者： Julian J. Lum , André A. Pilon , Jaime Sanchez-Dardon , Barbara N. Phenix , John E. Kim
DOI: 10.1128/JVI.75.22.11128-11136.2001
关键词: Antibody 、 Virology 、 In vitro 、 Biology 、 RNA 、 Jurkat cells 、 Molecular biology 、 Programmed cell death 、 Apoptosis 、 Tumor necrosis factor alpha 、 Cell culture
摘要: Because the persistence of human immunodeficiency virus (HIV) in cellular reservoirs presents an obstacle to viral eradication, we evaluated whether tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) induces apoptosis such reservoirs. Lymphocytes and monocyte-derived macrophages (MDM) from uninfected donors do not die following treatment with either leucine zipper TRAIL (LZhuTRAIL) or agonistic anti-TRAIL receptor antibodies. By contrast, vitro HIV-infected MDM as well peripheral blood lymphocytes patients, including CD4(+) CD45RO(+) HLA-DR(-) lymphocytes. In addition, LZhuTRAIL-treated cells produce less RNA p24 antigen than untreated controls. Whereas cultures large amounts HIV antigen, seven treated cell cultures, production was undetectable all, six, proviral DNA four. These data demonstrate that death types which harbor latent
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