Renal involvement in primary antiphospholipid syndrome.

摘要: Our objective was to define the renal involvement in primary antiphospholipid syndrome (APS). We studied 20 patients with APS. Fourteen were women, mean age 34.4 years. None met ARA criteria for systemic lupus erythematosus. All underwent complete function studies. The presence of hypertension also investigated. Renal disease found 5 patients, and characterized by proteinuria, failure. Kidney biopsy performed these showing thromboses microvasculature, mesangiolysis, mesangial interposition, electron lucent subendothelial material ischemic obsolescence glomeruli. Arterioles showed luminal narrowing due medial hypertrophy, mucoid thickening intima, thrombosis fibrosis. 25% our Biopsy findings consistent a thrombotic microangiopathy involving both arterioles glomerular capillaries.