Enhanced Functional Recovery in MRL/MpJ Mice after Spinal Cord Dorsal Hemisection
作者： Sandrine Thuret , Michaela Thallmair , Laura L Horky , Fred H Gage , None
DOI: 10.1371/JOURNAL.PONE.0030904
关键词: Gene expression 、 Microarray analysis techniques 、 Regeneration (biology) 、 Immunology 、 Spinal cord 、 Thoracic vertebrae 、 Corticospinal tract 、 Microglia 、 Spinal cord injury 、 Medicine 、 Pathology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Adult MRL/MpJ mice have been shown to possess unique regeneration capabilities. They are able heal an ear-punched hole or injured heart with normal tissue architecture and without scar formation. Here we present functional histological evidence for enhanced recovery following spinal cord injury (SCI) in mice. A control group (C57BL/6 mice) underwent a dorsal hemisection at T9 (thoracic vertebra 9). Our data show that recovered motor function significantly faster more completely. We observed of the corticospinal tract (CST). Furthermore, reduced astrocytic response fewer micro-cavities site, which appear create growth-permissive environment axons. suggest is part due lower lesion-induced increase cell proliferation post-SCI, differentiation proliferating cells. Interestingly, also found increased number microglia, could be involved repair mechanisms. Finally, evaluate molecular basis repair, examined difference gene expression changes C57BL/6 after SCI. microarray support our findings reveal transcriptional profile associated efficient
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