Spironolactone and Enalapril Differentially Up-Regulate the Expression of VEGF and Heme Oxygenase-1 in the Neonatal Rat Kidney
作者： HYUNG EUN YIM , JI HAE KIM , KEE HWAN YOO , IN SUN BAE , YOUNG SOOK HONG
DOI: 10.1203/PDR.0B013E3182114C38
关键词: Angiotensin II 、 Hypoxia (medical) 、 ACE inhibitor 、 Kidney 、 Endocrinology 、 Internal medicine 、 Aldosterone 、 Pimonidazole 、 Enalapril 、 Biology 、 Heme oxygenase
摘要: Both the renin-angiotensin-aldosterone system (RAAS) and hypoxia are vital physiological factors involved in control of nephrogenesis vascularization. We investigated relationship between RAAS developing kidney. The expression VEGF heme oxygenase (HO)-1 related with oxygen was analyzed enalapril- or spironolactone-treated neonatal rat kidneys. Enalapril (30 mg/kg/d) spironolactone (200 administered to newborn pups for 7 d. rats were injected i.p. pimonidazole mg/kg), a marker severe tissue hypoxia, 1 h before killing. HO-1 protein significantly increased by immunoblots immunohistochemistry both kidneys, compared controls (p < 0.05). mRNA group immunoactivity not different from that enalapril-treated group, whereas it group. results this study indicate aldosterone blockade angiotensin II inhibition kidney up-regulated renal regardless hypoxic conditions may differentially modulate production.
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