Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development

摘要: Osteoarthritis (OA) is the most common form of joint disease. This presents OA research community and pharmaceutical companies developing disease-modifying drugs (DMOADs) with great opportunities. The different subtypes complicate traditional approaches for new treatments. If we can identify markers that distinguish this could greatly facilitate drug development from early discovery to late clinical development. Nevertheless, current result in poorly targeted treatments inability recruit right patients trials. Thus, there an urgent medical need objective biomarker tools patient phenotyping.