Anticancer activity of natural and synthetic acetylenic lipids

摘要: This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to class molecules containing triple bond(s). They are found in plants, fungi, microorganisms, marine invertebrates. Although acetylenes common as components terrestrial bacteria, it only within the last 30 years biologically active polyacetylenes having unusual structural features been reported cyanobacteria, algae, invertebrates, other sources. Naturally occurring aquatic particular interest since many them display important biological activities possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, immunosuppressive properties. There no doubt they great interest, especially for medicinal and/or pharmaceutical industries. presents structures describes cytotoxic more than 300 derivatives isolated organisms.