A Viscidane Diterpene and Polyacetylenes from Cultures of Hypsizygus marmoreus
作者： Ling Zhang , Zheng-Hui Li , Ze-Jun Dong , Yan Li , Ji-Kai Liu
DOI: 10.1007/S13659-015-0058-2
关键词:
摘要: Investigation on the cultures of Hypsizygus marmoreus resulted in isolation a new viscidane diterpene, 8-oxoviscida-3,11(18)-diene-13,14,15,19-tetraol (1) and two polyacetylenes, (E)-10-(1,1-dimethyl-2-propenyloxy)-2-decene-4,6,8-triyn-1-ol (2) 10-(1,1-dimethyl-2-propenyloxy)deca-4,6,8-triyn-1-ol (3), together with known (E)-2-decen-4,6,8-triyn-1-ol (4) 4,6,8-decatriyn-1-ol (5). Their structures were elucidated basis extensive spectroscopic studies. Compound 1 is first finding diterpene mushrooms. Compounds 1, 3 5 tested for cytotoxicity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7 SW-480. None compounds showed cytotoxic activity (IC50 > 40 µM).
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