Cellulose Matrices for Zero-Order Release of Soluble Drugs
作者： K. V. Ranga Rao , K. Padmalatha Devi , P. Buri
DOI: 10.3109/03639048809152017
关键词: Beta-adrenergic blocking agent 、 Matrix (mathematics) 、 Dissolution testing 、 Polymer 、 Distilled water 、 Chromatography 、 Metoprolol Tartrate 、 Chemistry 、 Cellulose 、 Alprenolol
摘要: AbstractRelease of two very soluble beta adrenergic blockers namely: metoprolol tartrate and alprenolol HCl from cellulose matrices containing hydroxypropylcellulose (HPC) or sodium carboxymethylcellulose (Na CMC) methylcellulose (MC), MC + Na CMC HPC in different ratios was studied distilled water using USP dissolution apparatus 2. Increase the ratio total polymer to drug has decreased release rate a nonlinear manner. When only one (HPC used, profiles were first-order sigmoidal nature respectively. disintegrated < 1 h. By mixing with an optimum amount nonionic MC) anionic polymers, zero-order excellent reproducibility obtained. Rate erosion matrix 2.5 times higher when drug, present compared HPC. This indicates that diffusional pathlength for increases time whe...
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