Cytotoxic labdane diterpenoids from Croton oblongifolius.
作者： Sophon Roengsumran , Amorn Petsom , Narupat Kuptiyanuwat , Tirayut Vilaivan , Nattaya Ngamrojnavanich
DOI: 10.1016/S0031-9422(00)00358-7
关键词: Pharmacognosy 、 Bark 、 Euphorbiaceae 、 Cytotoxicity 、 Labdane 、 Diterpene 、 Biology 、 Stereochemistry 、 Terpenoid 、 Croton
摘要: Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures established by spectroscopic data, each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities all the lines; whereas first two compounds less active.
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