Neuroprotective labdane diterpenes from Fritillaria ebeiensis.
作者： Jing Xu , Cuizhou Liu , Ping Guo , Yuanqiang Guo , Da-Qing Jin
DOI: 10.1016/J.FITOTE.2011.03.009
关键词: Labdane 、 Two-dimensional nuclear magnetic resonance spectroscopy 、 Diterpene 、 Fritillaria 、 Neuroblastoma 、 Dopaminergic 、 Biology 、 Stereochemistry 、 Neuroprotection 、 Programmed cell death
摘要: Abstract By bioactivity-guided isolation, two labdane diterpenes (1 and 2) have been isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated as 6α,7β-dihydroxy-labda-8(17),12(E),14-triene (1) 6-oxo-2α-hydroxy-labda-7,12(E), 14-triene (2), on basis spectroscopic data analysis (IR, ESI-MS, HR-ESI-MS, 1D 2D NMR). Both isolates showed neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
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