Polymorphism of Filovirus Glycoproteins
作者： Viktor E. Volchkov , Valentina A. Volchkova , Olga Dolnik , Heinz Feldmann , Hans‐Dieter Klenk
DOI: 10.1016/S0065-3527(05)64011-0
关键词: RNA 、 Biology 、 Glycoprotein 、 Marburgvirus 、 Virology 、 Transmembrane domain 、 Gene 、 Amino acid 、 Genetics 、 Ebola virus 、 Ectodomain
摘要: Publisher Summary Filoviral glycoproteins are encoded by gene 4 (GP gene) of the nonsegmented negative-strand RNA genome. Nonstructural glycoprotein (sGP) as well Ebola virus (EBOV) and Marburgvirus (MBGV) GP undergo several posttranslational processing steps giving rise to a whole series different glycoproteins. Comparison sequences Marburg shows conservation at amino-terminal carboxy-terminal ends, whereas middle region is variable. can be subdivided into large ectodomain, lipid membrane-spanning domain approximately 30 amino acids, short cytoplasmic tail 8 respectively. Sequence comparison has revealed striking similarities between GP2 filoviruses transmembrane retroviruses. According data, contains hydrophobic fusion peptide distance 22 or 91 acids from terminus. Between domain, which flanked two cysteines, there amphipathic helices separated CX6CC motif. It indicated that maturation release in membrane-bound form does not depend on other viral proteins.
sci-hub.se 参考文章(107)
A. Stieneke-Gröber, M. Vey, H. Angliker, E. Shaw, G. Thomas, C. Roberts, H.D. Klenk, W. Garten, Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. The EMBO Journal. ,vol. 11, pp. 2407- 2414 ,(1992) , 10.1002/J.1460-2075.1992.TB05305.X
Gary J. Nabel, Zhi-yong Yang, Henricus J. Duckers, Nancy J. Sullivan, Anthony Sanchez, Elizabeth G. Nabel, Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury Nature Medicine. ,vol. 6, pp. 886- 889 ,(2000) , 10.1038/78645
Katja Althoff, Pranitha Reddy, Nicole Voltz, Stefan Rose-John, Jürgen Müllberg, Shedding of interleukin-6 receptor and tumor necrosis factor α European Journal of Biochemistry. ,vol. 267, pp. 2624- 2631 ,(2000) , 10.1046/J.1432-1327.2000.01278.X
H. Feldmann, H. D. Klenk, Ebola and Marburg Viruses: Molecular and Cellular Biology ,(2007)
Rouven J. Wool-Lewis, Paul Bates, Endoproteolytic Processing of the Ebola Virus Envelope Glycoprotein: Cleavage Is Not Required for Function Journal of Virology. ,vol. 73, pp. 1419- 1426 ,(1999) , 10.1128/JVI.73.2.1419-1426.1999
W. Schäfer, A. Stroh, S. Berghöfer, J. Seiler, M. Vey, M.L. Kruse, H.F. Kern, H.D. Klenk, W. Garten, Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. The EMBO Journal. ,vol. 14, pp. 2424- 2435 ,(1995) , 10.1002/J.1460-2075.1995.TB07240.X
K Nakayama, W.S. Kim, S Torii, M Hosaka, T Nakagawa, J Ikemizu, T Baba, K Murakami, Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. Journal of Biological Chemistry. ,vol. 267, pp. 5897- 5900 ,(1992) , 10.1016/S0021-9258(18)42638-5
E D Anderson, L Thomas, J S Hayflick, G Thomas, Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. Journal of Biological Chemistry. ,vol. 268, pp. 24887- 24891 ,(1993) , 10.1016/S0021-9258(19)74548-7
Kazuhisa NAKAYAMA, Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins Biochemical Journal. ,vol. 327, pp. 625- 635 ,(1997) , 10.1042/BJ3270625
S.S. Molloy, L. Thomas, J.K. VanSlyke, P.E. Stenberg, G. Thomas, Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. The EMBO Journal. ,vol. 13, pp. 18- 33 ,(1994) , 10.1002/J.1460-2075.1994.TB06231.X