Filoviruses and the balance of innate, adaptive, and inflammatory responses.

摘要: The Filoviruses Marburg virus and Ebola are among the deadliest of human pathogens, causing fulminant hemorrhagic fevers typified by overmatched specific immune responses profuse inflammatory responses. Keys to both vaccination treatment may reside, first, in understanding dysfunctions that parallel Filoviral disease and, second, devising ways redirect restore normal function as well mitigate inflammation. Here, we describe how infections subvert innate through perturbances dendritic cells neutrophils, with particular emphasis on downstream effects adaptive immunity We suggest pivotal events be subject therapeutic intervention encounter processes.