Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system
作者： S. Baize , E. M. Leroy , E. Mavoungou , S. P. Fisher-Hoch
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摘要: In fatal Ebola virus hemorrhagic fever massive intravascular apoptosis develops rapidly following infection and progressing relentlessly until death. While data suggest that T lymphocytes are mainly deleted by in PBMC of human cases, experimental animal models have shown some evidence destruction spleen lymph nodes probably involving both B cells. Nevertheless, we able to conclude from the accumulated early interactions between immune system, via macrophages, main targets for viral replication, lead cells cases.
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