Comparative Pathogenesis of Crimean-Congo Hemorrhagic Fever and Ebola Hemorrhagic Fever

摘要: Crimean-Congo hemorrhagic fever (CCHF) virus has been called “the Asian Ebola virus” – an epithet that recognizes the close clinical resemblance of CCHF and (EHF), also suggests two illnesses share similar underlying mechanisms [38]. EHF both present difficult challenges to pathophysiology research, because they occur principally in regions lacking a modern medical infrastructure high virulence their causative agents requires laboratory studies be performed under Biosafety Level 4 (BSL-4) containment. Efforts elucidate pathogenesis have even further handicapped by failure cause disease animals other than suckling mice. By contrast, models adult mice, guinea pigs, nonhuman primates employed extensively for [7, 13, 24]. Detailed examination parameters, pathologic changes, innate immune responses cynomolgus macaques over entire course fatal especially valuable elucidating how pathogen overcomes host defenses rapidly overwhelming infection. These findings are leading novel approaches postexposure prophylaxis therapy [10, 14, 20, 35]. Despite lack animal CCHF, much can still learned about its through properly designed prospective patients vitro experiments employing virus-infected human cells. This chapter discusses recent progress could help guide such providing hypotheses testing.