Ebola virus selectively inhibits responses to interferons, but not to interleukin-1beta, in endothelial cells.
作者： Brian H. Harcourt , Anthony Sanchez , Margaret K. Offermann
DOI: 10.1128/JVI.73.4.3491-3496.1999
关键词: Interleukin 、 Biology 、 Interferon gamma 、 Ebola virus 、 MHC class I 、 Ebolavirus 、 Virology 、 Alpha interferon 、 Major histocompatibility complex 、 Transcription factor
摘要: Ebola virus infection is highly lethal and leads to severe immunosuppression. In this study, we demonstrate that of human umbilical vein endothelial cells (HUVECs) with Zaire (EZ) suppressed basal expression the major histocompatibility complex class I (MHC I) family proteins inhibited induction multiple genes by alpha interferon (IFN-alpha) IFN-gamma, including those coding for MHC proteins, 2'-5' oligoadenylate synthetase [2'-5'(A)N], IFN regulatory factor 1 (IRF-1). Induction interleukin-6 (IL-6) ICAM-1 IL-1beta was not EZ, suggesting inhibition signaling specific. Gel shift analysis demonstrated EZ blocked IFNs nuclear bind IFN-stimulated response elements, gamma activation sequences, binding site (IRF-E). contrast, did block transcription NF-kappaB IL-1beta. The events lead blockage may be critical virus-induced immunosuppression would play a role in pathogenesis infection.
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