Therapy of Ebola and Marburg virus infections

摘要: The filoviruses, Marburg and Ebola, cause fulminant hemorrhagic fever in humans nonhuman primates. agents replicate to high titer macrophages dendritic cells, suppressing type I interferon responses, disseminate these other cell types tissues throughout the body, causing extensive necrosis inducing an intense systemic inflammatory response resembling septic shock. Effective therapies are urgently needed deal with laboratory accidents, natural epidemics threat of bioterrorism. An immediate goal should be development postexposure prophylaxis for persons who have been exposed or Ebola virus, but not yet become ill. This article first reviews current research aimed at blocking individual steps filoviral replication pathway, then describes efforts characterize modify damaging host responses. No direct inhibitors identified, some interventions that counteract suppression responses shown benefit animal models lethal infection.