作者: Jennifer L. Bankers-Fulbright , Kimberly R. Kalli , David J. McKean
DOI: 10.1016/0024-3205(96)00135-X
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摘要: Interleukin-1 (IL-1) is primarily an inflammatory cytokine, although it capable of mediating a wide variety effects on many different cell types. Nearly every known signal transduction pathway has been reported to be activated in response IL-1. However, the significance these signaling events unclear, due use and sometimes unique lines studying IL-1-initiated transduction. Complicating matters further lack association studies between identified IL-1-induced signals subsequent biological responses. In this article, we review what about IL-1 receptor and, whenever possible, correlate