The immune response of mice to antigen in macrophages.

摘要: Peritoneal macrophages obtained following an injection of proteose peptone, and after uptake Maia squinado haemocyanin were transferred to syngeneic hosts. Immunogenicity was tested by the capacity containing antigen prime normal or irradiated (660–700 r) recipients for a secondary immune challenge. The immunogenicity depended on interaction with immunocompetent lymphoid cells since hosts unresponsive unless also supplied. For optimal response live had gain access organs. Depending amount macrophages, recipient mice synthesized challenge 7S and/or 19S antibody. kinetics in similar those seen when using free soluble material except some quantitative differences. Although dependent total dose somewhat higher antibody titres having high antigen—cell ratio. Antigen could elicit primed mice. macrophage-held not impaired X-irradiation macrophage donors.