Inducible, Cell-Targeted Mutations In Mice: New Tools For Genetically Dissecting Behavior

摘要: The first generation of genetic mutations in mice, conventional transgenics and knockouts, have provided important new insights into many aspects brain function, including complex behavior. Moreover, as variants that contribute to the development mental disorders are found, mice bearing these genes represent novel powerful animal models disorders. However, complicated by fact they generally occur at early stages perhaps most tissues body. This complicates use for studies gene function adult organisms. last five years has seen second which mutation (either loss or addition a gene) can be controlled temporally spatially, is, induced animals targeted particular region neuronal cell type. Although not yet routine, such inducible cell-type specific tools understand role