Incidence and characteristics of peripheral neuropathy during oxaliplatin-based chemotherapy for metastatic colon cancer

摘要: Aim. The current prospective study sought to trace the incidence and severity of oxaliplatin-induced peripheral neuropathy (OXLIPN) determine its clinical electrophysiological pattern. Patients methods. Twenty-five adult patients scheduled be treated with 12 courses oxaliplatin-based regimen, FOLFOX-4, for metastatic colon cancer participated in this study. were clinically electrophysiologically monitored at baseline followed-up during chemotherapy. OXLIPN was summarized by means a modified Total Neuropathy Score (TNS). Results. Evidence disclosed 16 25 (64%). mean TNS values manifesting some grade 13.9±5.8 (range 7–28). All longitudinal comparisons concerning motor conduction parameters failed reach significance. By contrast, median changes each follow-up studies revealed significant decrease all sensory action potentials examine...