Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study.
作者： A de Gramont , J F Bosset , C Milan , P Rougier , O Bouché
DOI: 10.1200/JCO.1997.15.2.808
关键词: FOLFIRI Regimen 、 Fluorouracil 、 Anesthesia 、 Bolus (medicine) 、 Chemotherapy 、 Perfusion 、 Randomized controlled trial 、 Medicine 、 Rectum 、 Regimen
摘要: PURPOSEThis multicenter study compared the therapeutic ratio of a monthly schedule low-dose leucovorin (LV) and fluorouracil (5-FU) bolus with bimonthly high-dose LV 5-FU plus continuous infusion in patients advanced colorectal cancer.PATIENTS AND METHODSOf 448 randomly assigned to treatment, 433 were assessable. Treatment A was regimen intravenous (IV) 20 mg/m2 425 for 5 days every 4 weeks. B IV 200 as 2-hour followed by 400 22-hour 600 2 consecutive Therapy continued until disease progression. Second-line chemotherapy, which included infusion, allowed both arms.RESULTSThe response rates 348 measurable lesions 14.4% (monthly regimen) 32.6% (bimonthly (P = .0004). The median progression-free survival times 22 weeks 2...
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