A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas.

摘要: The combination of high-dose folinic acid with 5-fluorouracil has shown improved response rates in several trials advanced colorectal carcinoma. This however is at the expense increased toxicity: regimens using weekly bolus injections produce diarrhoea most patients and occasional toxic deaths from this, whilst those daily for one week four report both severe oral mucositis. Both types regimen have significant myelosuppression. A recent described a different schedule acid, which appeared better tolerated but equally active (De Gramont et al., 1988). Here we results same programme, 64 adenocarcinomas. (Forty three colorectal, ten gastric, six pancreatic five unknown primary.) Patients received 200 mg m-2 by infusion over 2 h followed an IV 400 then 22 h. was repeated next 24 given every weeks total to 12 courses depending upon response. overall rate 26% 62 evaluable patients. No toxicity greater than WHO Grade II occurred. Diarrhoea mucositis did occur around 10% treatments were not troublesome. febrile neutropenic episodes seen. Despite previous reports only modest activity this against stomach cancers, demonstrates low retains good palliative treatment gastric colonic