Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation.

摘要: PURPOSETo determine if fluorouracil (FUra) has different mechanisms of action as a function the dose schedule used.DESIGNThe preclinical and clinical literature relating toxicity antitumor effects FUra its schedule, with without modulating agents, was reviewed.RESULTSThe data support hypothesis that may be considered to two drugs, depending on (bolus v continuous infusion [CI]).CONCLUSIONThese results suggest additional therapeutic benefit obtained from regimens by (1) appropriate schedule-dependent modulation, (2) sequential or alternating use cycles bolus followed CI appropriately modulated, (3) hybrid regimens, ie, those contain both pulse schedules.