Prognostic significance of p53 overexpression in gastric and colorectal carcinoma

摘要: p53 expression was examined in 55 gastric and 107 colorectal carcinomas with an immunoperoxidase technique, using the polyclonal antibody CM1 on routinely fixed, paraffin embedded tissue. protein detected 47% 46% found to correlate stage of disease unfavourable clinical outcome (P less than 0.001). Thus, proportion positively reacting neoplasms increased as progressed, tumours which had invaded regional lymph-nodes overexpressed more frequently localised elevated level associated early relapse death. In carcinoma positivity also linked site macroscopic configuration primary tumour most expressed from rectum ulcerative tumours. overexpression irrespective grade. Uniform negative reactivity anti-p53 seen normal epithelium adjacent carcinoma, intestinal metaplasia, atrophic gastritis colonic adenomas. There a good correlation between immunohistochemical staining frozen sections. These studies suggest that detection fixed tissue can be used along other established parameters assess prognostic outcome, especially identify patients poor short-term prognosis.