Randomized phase III Study of 5‐fluorouracil plus high dose folinic acid versus 5‐fluorouracil plus folinic acid plus methyl‐lomustine for patients with advanced colorectal cancer
作者： Dennie V. Jones , Roger J. Winn , Barry W. Brown , Lawrence B. Levy , Reginald P. Pugh
DOI: 10.1002/1097-0142(19951115)76:10<1709::AID-CNCR2820761006>3.0.CO;2-5
关键词: Surgery 、 Folinic acid 、 Internal medicine 、 Fluorouracil 、 Chemotherapy 、 Lomustine 、 Regimen 、 Colorectal cancer 、 Medicine 、 Randomized controlled trial 、 Gastroenterology 、 Nitrosourea
摘要: Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine a nitrosourea with modest activity against cancer. A randomized trial was undertaken evaluate the impact addition methyl-lomustine would have on response, duration survival, survival in patients advanced Methods. methyl-lomustine/5-FU/Leucovorin (MFL) consisted (110 mg/ m2), administered Day 1 each 8-week cycle six weekly boluses 5-FU (600 mg/m2), Leucovorin (500 mg/mz). FL treatment arm administration as described above. Patients were evaluated for toxicity after cycle.
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