Method Development and Validation of Amlodipine, Gliquidone and Pioglitazone: Application in the Analysis of Human Serum
作者： Agha Zeeshan Mirza , M Saeed Arayne , Najma Sultana , None
DOI: 10.1080/22297928.2014.1000965
关键词: Chemistry 、 Phosphoric acid 、 Gliquidone 、 Pioglitazone 、 High-performance liquid chromatography 、 Glibenclamide 、 Amlodipine 、 Analyte 、 Chromatography 、 Detection limit
摘要: AbstractA sensitive LC method has been developed for the simultaneous determination of co-administered drugs amlodipine, gliquidone and pioglitazone in bulk drug, pharmaceutical formulations, human serums. The assay involved an isocratic elution analytes on a Purospher® STAR RP-18 end capped (5 μm, 25 x 0.46 cm) column at ambient temperature with mobile phase consisting methanol: water: acetonitrile (80:10:10 v/v/v) flow rate 0.7 mLmin-1 230 nm. pH was adjusted to 3.50 phosphoric acid glibenclamide used as internal standard. linearity found be 5-50 μgmL–1 all correlation coefficients were 0.9991, 0.9992 0.9963; limit detection 0.34, 0.06 0.33 pioglitazone, respectively. All validated parameters acceptable range. recovery rates 98.2-101.53 %, 100.40-101.60 % 98.25-101.20 serum a...
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